World leader in adaptogens

CHISAN - ADAPT-232 - STUDIES

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Swedish Herbal Institute’s first adaptogen product, Eleuthero was launched already in the early 70-ties. The product was called “Russian Root” and an innovation – nothing else existing on the market with such pronounced fast and energetic effect. This made our Mr. Wikman to make a thorough research also on other adaptogen plants and then made his first synergy product based on the three adaptogen plants; Roseroot, Eleuthero and Schisandra. This product was registered 1979 and changed the Swedish health market. After a couple of years of more research we started testing together with space crew performing difficult tasks when training isolated on a station on earth with the same conditions as in space. This research lead to our second generation of adaptogens where we optimized the combination and named it ADAPT-232. The space crew then used the adaptogen combination in space when performing difficult tasks both inside and outside the space shuttle to be more alert and get extra energy.

After a couple of years with more research to strengthen the strong synergy effect from the combined adaptogens – pantothenic acid was added. Pantothenic acid improves the already strong synergy effect of the combined adaptogens. And the third generation of adaptogens – ADAPT-232S with Roseroot, Eleuthero, Schisandra and pantothenic acid – is here to revolutionize again!

 

The EFSA registered health claims of the adaptogen plants in the patented extract ADAPT-232S are; Roseroot contributes to optimal mental and cognitive activity, as well as physical performance, Schisandra helps to restore physical and mental well-being, Eleuthero contributes to more physical energy in case of fatigue and tiredness. Roseroot, Schisandra and Eleuthero has adaptogenic effect. Adaptogens are one category natural substances that help maintain normal bodily functions and systems when these are exposed to stress.

 

Here is a selection of our studies…

 

CHISAN /ADAPT-232 REDUCE FATIGUE IN LONG COVID

Efficacy of Adaptogens in Patients with Long COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial: Karosanidze I, Kiladze U, Kirtadze N, Giorgadze M, Amashukeli N, Parulava N,

Iluridze N, Kikabidze N, Gudavadze N, Gelashvili L, Koberidze V, Gigashvili E, Jajanidze N, Latsabidze N, Mamageishvili N, Shengelia R, Hovhannisyan A, Panossian A. Pharmaceuticals 2022, 15, 345. https://doi.org/10.3390/ph15030345

 

TRAIN BETTER – SPEED UP RECOVERY – BETTER TOLERANCE TO STRESS WITH ADAPT

Efficacy of Adaptogenic Supplements on Adapting to Stress: A Randomized, Controlled Trial.

Hovhannisyan A, Nylander M, Wikman G, Panossian A. Journal of Athletic Enhancement. 2015, 4:4. doi:10.4172/2324-9080.1000205. http://dx.doi.org/10.4172/2324-9080.1000205

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ADAPT-232 IMPROVES MANY ASPECTS OF MENTAL DISORDERS PARTICULARLY UNDER STRESS

Adaptogens in Mental and Behavioral Disorders. Panossian AG. Psychiatr Clin North Am. 2013 Mar;36(1):49-64. doi: 10.1016/j.psc.2012.12.005. https://pubmed.ncbi.nlm.nih.gov/23538076/

 

MOLECULAR MARKERS OF ADAPTOGENIC ANTI-STRESS ACTIVITY ESTABLISHED

Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts. Asea A, Kaur P, Panossian A, Wikman GK. Phytomedicine. 2013 Nov 15;20(14):1323-9. doi: 10.1016/j.phymed.2013.07.001. https://pubmed.ncbi.nlm.nih.gov/23920279/

 

SYNERGY DEMONSTRATED WITH THE ACTIVE CONSTITUENTS OF ADAPT-232

Synergy and antagonism of active constituents of ADAPT-232 on transcriptional level of metabolic regulation of isolated neuroglial cells. Panossian A, Hamm R, Kadioglu O, Wikman G, Efferth T.

Front Neurosci. 2013 Feb 20;7:16. doi: 10.3389/fnins.2013.00016. https://pubmed.ncbi.nlm.nih.gov/23430930/

 

A SINGLE DOSE ADAPT-232 REDUCES STRESS AND INCREASES COGNITIVE CAPACITY IN WOMEN

Double-blind, placebo-controlled, randomised study of single dose effects of Adapt-232 on cognitive functions. Aslanyan G, Amroyan E, Gabrielyan E, Nylander M, Wikman G, Panossian A. Phytomedicine. 2010 Jun;17(7):494-9. doi: 10.1016/j.phymed.2010.02.005. Epub 2010 Apr 5.

https://pubmed.ncbi.nlm.nih.gov/20374974/

 

ADAPT-232 EFFECTS CNS AND IS STRESS-PROTECTIVE

Effects of adaptogens on the Central Nervous System and the Molecular Mechanisms associated with their stress-protective activity. Panossian A, Georg W. Pharmaceuticals (Basel). 2010 Jan; 3(1): 188–224. doi: 10.3390/ph3010188. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991026/

 

CHISAN / ADAPT-232 SPEED UP RECOVERY FROM NON-SPECIFIC PNEUMONIA

Impact of Chisan® (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia. Narimanian M, Badalyan M, Panosyan V, Gabrielyan E, Panossian A, Wikman G, Wagner H. Phytomedicine. 2005 Nov;12(10):723-9. doi: 10.1016/j.phymed.2004.11.004. https://pubmed.ncbi.nlm.nih.gov/16323290/

 

ADAPT-232 GIVES BETTER MEMORY AND ANTI-STRESS EFFECT IN ISOLATED SPACE CREW

Evaluation of the effect of a single dose of a phytoadaptogen on the working capacity of human subjects during prolonged isolation. Bogatova RI, Shlykova LV, Salnitsky VP, Wikman G.

Aerospace and Environmental Medicine (Aviakosm Ekolog Med ). 1997;31(4):51-4. https://pubmed.ncbi.nlm.nih.gov/9424198/