Peer reviewed publications

 

Clinical studies on Kan Jang Andrographis

 

NO RUNNY NOSE AND FASTER RECOVERY WITH KAN JANG

Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang® and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children. Spasov AA, Ostrovskij OV, Chernikov MV, Wikman G. Phytotherapy Research. 2004 Jan;18(1):47-53. doi: 10.1002/ptr.1359. https://pubmed.ncbi.nlm.nih.gov/14750201/

 

REDUCES DAYS OF SICK LEAVE ABD POST-INFLUENZA COMPLICATIONS

A randomized controlled study of Kan Jang versus Amantadine in the treatment of influenza in Volgograd. Kulichenko LL, Kireyeva LV, Malyshkina EN, Wikman G. Journal of Herbal Pharmacotherapy. 2003;3(1):77-93.

https://pubmed.ncbi.nlm.nih.gov/15277072/

 

TREATS URTI AND SINUSITIS

A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Gabrielian ES, Shukarian AK, Goukasova GI, Chandanian GL, Panossian AG, Wikman G, Wagner H. Phytomedicine. 2002 Oct;9(7):589-97. doi: 10.1078/094471102321616391.

https://pubmed.ncbi.nlm.nih.gov/12487322/

 

TREATS URTI AND SINUSITIS

Double blind placebo-controlled pilot and Phase III study of a standardised Andrographis paniculata Herba Nees extract fixed combination (Kan jang) in the treatment of uncomplicated upper respiratory tract infection. Melchior J, Spasov AA, Ostrovskij OV, Bulanov AE, Wikman G.

 Phytomedicine. 2000 Oct;7(5):341-50. doi: 10.1016/S0944-7113(00)80053-7. https://pubmed.ncbi.nlm.nih.gov/11081985/

3-MONTH WINTER STUDY – KAN JANG PREVENTS COMMON COLD

Prevention of common colds with Andrographis paniculata dried extract. A pilot double blind trial.

Cáceres DD, Hancke JL, Burgos RA, Wikman GK. Phytomedicine. 1997 Jun;4(2):101-4. doi: 10.1016/S0944-7113(97)80051-7. https://pubmed.ncbi.nlm.nih.gov/23195395/

 

PREVENTS COMMON COLD AND REDUCES THE NUMBER OF SICK DAYS

Controlled clinicals study of standardized Andrographis paniculata extract in common cold - a pilot trial. Melchior J, Palm S, Wikman G. Phytomedicine. 1997 Feb;3(4):315-8. doi: 10.1016/S0944-7113(97)80002-5. https://pubmed.ncbi.nlm.nih.gov/23195187/

REDUCING COMMON COLD

Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double-blind placebo study. Cáceres DD, Hancke JL, Burgos RA, Sandberg F, Wikman GK. Phytomedicine. 1999 Oct;6(4):217-23. doi: 10.1016/S0944-7113(99)80012-9.

https://pubmed.ncbi.nlm.nih.gov/10589439/

 

RESISTANCE TO COMMON COLD

A double-blind study with a new monodrug Kan Jang: Decrease of symptoms and improvement in the recovery from common colds. Hancke JL, Burgos R, Cáceres DD, Wikman G. Phytotherapy Research. 1995;9:559-562.

Clinical and other studies on ADAPT-232 extract combination

TRAIN BETTER – SPEED UP RECOVERY – BETTER TOLERANCE TO STRESS WITH ADAPT

Efficacy of Adaptogenic Supplements on Adapting to Stress: A Randomized, Controlled Trial.

Hovhannisyan A, Nylander M, Wikman G, Panossian A. Journal of Athletic Enhancement. 2015, 4:4. doi:10.4172/2324-9080.1000205. http://dx.doi.org/10.4172/2324-9080.1000205

 

ADAPT-232 IMPROVES MANY ASPECTS OF MENTAL DISORDERS PARTICULARLY UNDER STRESS

Adaptogens in Mental and Behavioral Disorders. Panossian AG. Psychiatr Clin North Am. 2013 Mar;36(1):49-64. doi: 10.1016/j.psc.2012.12.005. https://pubmed.ncbi.nlm.nih.gov/23538076/

 

MOLECULAR MARKERS OF ADAPTOGENIC ANTI-STRESS ACTIVITY ESTABLISHED

Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts. Asea A, Kaur P, Panossian A, Wikman GK. Phytomedicine. 2013 Nov 15;20(14):1323-9. doi: 10.1016/j.phymed.2013.07.001. https://pubmed.ncbi.nlm.nih.gov/23920279/

 

SYNERGY DEMONSTRATED WITH THE ACTIVE CONSTITUENTS OF ADAPT-232

Synergy and antagonism of active constituents of ADAPT-232 on transcriptional level of metabolic regulation of isolated neuroglial cells. Panossian A, Hamm R, Kadioglu O, Wikman G, Efferth T.

Front Neurosci. 2013 Feb 20;7:16. doi: 10.3389/fnins.2013.00016. https://pubmed.ncbi.nlm.nih.gov/23430930/

A SINGLE DOSE ADAPT-232 REDUCES STRESS AND INCREASES COGNITIVE CAPACITY IN WOMEN

Double-blind, placebo-controlled, randomised study of single dose effects of Adapt-232 on cognitive functions. Aslanyan G, Amroyan E, Gabrielyan E, Nylander M, Wikman G, Panossian A. Phytomedicine. 2010 Jun;17(7):494-9. doi: 10.1016/j.phymed.2010.02.005. Epub 2010 Apr 5.

https://pubmed.ncbi.nlm.nih.gov/20374974/

 

ADAPT-232 EFFECTS CNS AND IS STRESS-PROTECTIVE

Effects of adaptogens on the Central Nervous System and the Molecular Mechanisms associated with their stress-protective activity. Panossian A, Georg W. Pharmaceuticals (Basel). 2010 Jan; 3(1): 188–224. doi: 10.3390/ph3010188. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991026/

 

CHISAN / ADAPT-232 SPEED UP RECOVERY FROM NON-SPECIFIC PNEUMONIA

Impact of Chisan® (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia. Narimanian M, Badalyan M, Panosyan V, Gabrielyan E, Panossian A, Wikman G, Wagner H. Phytomedicine. 2005 Nov;12(10):723-9. doi: 10.1016/j.phymed.2004.11.004. https://pubmed.ncbi.nlm.nih.gov/16323290/

 

ADAPT-232 GIVES BETTER MEMORY AND ANTI-STRESS EFFECT IN ISOLATED SPACE CREW

Evaluation of the effect of a single dose of a phytoadaptogen on the working capacity of human subjects during prolonged isolation. Bogatova RI, Shlykova LV, Salnitsky VP, Wikman G.

Aerospace and Environmental Medicine (Aviakosm Ekolog Med ). 1997;31(4):51-4. https://pubmed.ncbi.nlm.nih.gov/9424198/

Clinical studies of SHR-5 rhodiola rosea 


SHR-5 VS SETRALINE – MILD TO MODERATE DEPRESSION - SHR-5 HAD SOMEWHAT LESS ANTIDEPRESSANT EFFECT BUT WAS BETTER TOLERATED WITH NO ADVERSE EFFECTS.
Rhodiola rosea vs. sertraline for major depressive disorder: A randomized placebo-controlled trial.
Mao JJ, Xie SX, Zee J, Soeller I, Li QS, Rockwell K, Amsterdam JD. Phytomedicine. 2015 Mar 15;22(3):394-9. doi: 10.1016/j.phymed.2015.01.010. https://pubmed.ncbi.nlm.nih.gov/25837277/

STUDY PROTOCOL WITH SHR-5 TREATMENT IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER
Rhodiola rosea therapy for major depressive disorder: A study protocol for a randomized, double-blind, placebo-controlled trial. Mao JJ, Li QS, Soeller I, Xie SX, Amsterdam JD. Journal of Clinical Trials.  2014 Jun 20;4:170. doi: 10.4172/2167-0870.1000170. https://pubmed.ncbi.nlm.nih.gov/25610752/

SHR-5 TREAT STRESSED BURNOUT PATIENTS WITH FATIGUE SYNDROME
A randomised, double-blind, placebo-controlled, parallell-group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
Olsson EMG, Von Schéele B, a. Panossian AG. Planta Med. 2009 Feb;75(2):105-12. doi: 10.1055/s-0028-1088346. https://pubmed.ncbi.nlm.nih.gov/19016404/

SHR-5 TREATS PATIENTS WITH MILD TO MODERATE DEPRESSION
Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression.
Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Nordic Journal of Psychiatry. 2007;61(5):343-8. doi: 10.1080/08039480701643290. https://pubmed.ncbi.nlm.nih.gov/17990195/

STUDY ON NORMAL AND DOUBLE DOSE SHR-5 ON CADETS DURING MENTAL WORK – NORMAL DOSAGE IS ENOUGH 
A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Shevtsov VA, Zholus BI, Shervarly VI, Vol’skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. Phytomedicine. 2003 Mar;10(2-3):95-105. doi: 10.1078/094471103321659780. https://pubmed.ncbi.nlm.nih.gov/12725561/

SHR-5 INCREASE MENTAL PERFORMANCE DURING PHYSICIANS NIGHT DUTY
Rhodiola rosea in stress induced fatigue – A double blind cross-over study of a standardized extract SHA-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. 
Phytomedicine. 2000 Oct;7(5):365-71. doi: 10.1016/S0944-7113(00)80055-0.

https://pubmed.ncbi.nlm.nih.gov/11081987/

SHR-5 IMPROVES STUDY RESULTS DURING STRESSFUL EXAMINATION PERIODS
A double-blind placebo-controlled pilot study of the stimulating effect of Rhodiola rosea SHR-5 extract on the physical and mental work capacity of students during a stressful examination period with a repeated low-dose regimen. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. Phytomedicine. 2000 Apr;7(2):85-9. doi: 10.1016/S0944-7113(00)80078-1.

https://pubmed.ncbi.nlm.nih.gov/10839209/