Publikationer

Farmakologisk och klinisk forskning

 

Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells.
Panossian A, Hamm R, Kadioglu O, Wikman G, Efferth T.
Front Neurosci. 2013;7:16. doi: 10.3389/fnins.2013.00016. Epub 2013 Feb 20.

 

Adaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cells.
Panossian A, Wikman G, Kaur P, Asea A.
Front Neurosci. 2012;6:6. doi: 10.3389/fnins.2012.00006. Epub 2012 Feb 1.

 

Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT232 on cognitive functions
G. Aslanyan, E. Amroyan, E. Gabrielyan, M. Nylander, G. Wikman, A. Panossian
Phytomedicine , vol. 17, no. 7, pp. 494-499, 2010

 

Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy
A. Panossian, G. Wikman, J. Sarris
Phytomedicine , vol. 17, no. 7, pp. 481-493, 2010

 

Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
Panossian A, Wikman G.
Curr Clin Pharmacol. 2009 Sep;4(3):198-219. Epub 2009 Sep 1. Review.

 

Molecular chaperons mediated pathways of stress protective and anti-aging effects of adaptogens
A Panossian, G Wikman, P Kaur, A Asea
Planta Medica - PLANTA MED , vol. 75, no. 09, 2009

 

Evidence based efficacy of adaptogens in fatigue
A Panossian, G Wikman
Planta Medica - PLANTA MED , vol. 75, no. 09, 2009

 

Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones.
Panossian A, Wikman G, Kaur P, Asea A.


Phytomedicine. 2009 Jun;16(6-7):617-22. doi: 10.1016/j.phymed.2008.12.003. Epub 2009 Feb 1.

 

Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats.


Panossian A, Hovhannisyan A, Abrahamyan H, Gabrielyan E, Wikman G.
Phytother Res. 2009 Mar;23(3):351-7. doi: 10.1002/ptr.2631.

 

Adaptogens exert a stress protective effect by modulation of expression of molecular chaperons
A Panossian, G Wikman, L Andreeva, A Boykova, D Nikiforova, N Timonina
Planta Medica - PLANTA MED , vol. 74, no. 09, 2008

 

Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine.
Panossian A, Wikman G.


J Ethnopharmacol. 2008 Jul 23;118(2):183-212. doi: 10.1016/j.jep.2008.04.020. Epub 2008 Apr 24. Review.

Plant adaptogens increase lifespan and stress resistance in C. elegans
F. A. C. Wiegant, S. Surinova, E. Ytsma, M. Langelaar-Makkinje, G. Wikman, J. A. Post
Biogerontology , pp. 1-16, 2008

 

Comparative study of Rhodiola preparations on behavioral despair of rats
A. Panossian, N. Nikoyan, N. Ohanyan, A. Hovhannisyan, H. Abrahamyan, E. Gabrielyan, G. Wikman
Phytomedicine , vol. 15, no. 1, pp. 84-91, 2008

 

The efficacy of multi-drug therapy for the common cold with particular reference to Kan Jang fixed combination
G Wikman, A Panossian
Planta Medica - PLANTA MED , vol. 73, no. 09, 2007

 

The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol.
Panossian A, Hambardzumyan M, Hovhanissyan A, Wikman G.
Drug Target Insights. 2007;2:39-54. Epub 2007 Feb 16.

 

Methods of phytochemical standardisation of rhizoma cimicifugae racemosae
A. Panossian, A. Danielyan, G. Mamikonyan, G. Wikman
Phytochemical Analysis - PHYTOCHEM ANALYSIS , vol. 17, no. 3, pp. 208-208, 2006

 

Impact of Chisan ® (ADAPT232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia
M. Narimanian, M. Badalyan, V. Panosyan, E. Gabrielyan, A. Panossian, G. Wikman, H. Wagner
Phytomedicine , vol. 12, no. 10, pp. 723-729, 2005

 

Randomized trial of a fixed combination (KanJang ®) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections
M. Narimanian, M. Badalyan, V. Panosyan, E. Gabrielyan, A. Panossian, G. Wikman, H. Wagner
Phytomedicine , vol. 12, no. 8, pp. 539-547, 2005

 

Methods of phytochemical standardisation of rhizome Cimicifugae racemosae
A. Panossian, A. Danielyan, G. Mamikonyan, G. Wikman
Phytochemical Analysis - PHYTOCHEM ANALYSIS , vol. 15, no. 2, pp. 100-108, 2004

 

Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard ® – a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever
G. Amaryan, V. Astvatsatryan, E. Gabrielyan, A. Panossian, V. Panosyan, G. Wikman
Phytomedicine , vol. 10, no. 4, pp. 271-285, 2003

 

A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work
V. A. Shevtsov, B. I. Zholus, V. I. Shervarly, V. B. Vol'skij, Y. P. Korovin, M. P. Khristich, N. A. Roslyakova, G. Wikman
Phytomedicine , vol. 10, no. 2, pp. 95-105, 2003

 

A Randomized, Controlled Study of Kan Jang versus Amantadine in the Treatment of Influenza in Volgograd
L. L. Kulichenko, L. V. Kireyeva, E. N. Malyshkina, G. Wikman
Journal of Herbal Pharmacotherapy , vol. 3, no. 1, pp. 77-93, 2003

 

Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human
A. Panossian, A. Hovhannisyan, G. Mamikonyan, H. Abrahamian, E. Hambardzumyan, E. Gabrielian, G. Goukasova, G. Wikman, H. Wagner
Phytomedicine , vol. 7, no. 5, pp. 351-364, 2000

 

Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation
E. Amroyan, E. Gabrielian, A. Panossian, G. Wikman, H. Wagner
Phytomedicine , vol. 6, no. 1, pp. 27-31, 1999

 

Reduction of serum hepatic transaminases and CPK in sport horses with poor performance treated with a standardized Schizandra chinensis fruit extract
J. Hancke, R. Burgos, D. Cáceres, F. Brunetti, A. Durigon, G. Wikman
Phytomedicine , vol. 3, no. 3, pp. 237-240, 1996

 

Toxicological assessment ofAralia mandshurica (Araliaceae) root extract after subchronic administration in rats. A biochemical and histological study
Rafael Burgos, Juan Hancke, Georg Wikman, Victor Cubillos, Elías Caballero, Mauricio Oyarzo, Nury Sánchez
Phytotherapy Research - PHYTOTHER RES , vol. 8, no. 1, pp. 1-9, 1994